A patient is being evaluated for hyperaldosteronism, and the physician needs to ensure accurate results from the diagnostic assay. Which of the following drugs must be discontinued before performing the assay?
A. Spironolactone
B. Calcium channel blocker
C. Fluconazole
D. Oral contraceptive pills
The Correct Answer: A. Spironolactone
Explanation:
– Spironolactone (A): Spironolactone is a potassium-sparing diuretic and aldosterone antagonist. It can interfere with the measurement of aldosterone levels, leading to misleading results. Therefore, it should be discontinued before performing diagnostic assays for hyperaldosteronism to avoid false results.
Explanation of Other Options:
– Calcium Channel Blocker (B): Calcium channel blockers do not significantly affect aldosterone levels or the assay for hyperaldosteronism, so they do not need to be stopped before testing.
– Fluconazole (C): Fluconazole is an antifungal medication and does not affect aldosterone levels or the diagnostic assay for hyperaldosteronism.
– Oral Contraceptive Pills (D): Oral contraceptive pills can affect sex hormone levels but do not typically interfere with aldosterone assays. They generally do not need to be discontinued for testing hyperaldosteronism.
In summary, spironolactone must be stopped before performing an assay for diagnosing hyperaldosteronism, making option A the correct choice.